Tetrodotoxin citrate

Research use only, not for human use.

Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6.

Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6; Tetrodotoxin-sensitive sodium channel (Nav) family includes Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, and Nav1.7, the Nav1.5, Nav1.8, and Nav1.9 channels are TTX-resistant; inhibits the firing of action potentials in neurons by binding to the voltage-gated sodium channels in nerve cell membranes and blocking the passage of sodium ions into the neuron.Pain Phase 3 Clinical.

——

——

TTx citrate

Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

Neurological Disease

Pain

18660-81-6

511.3915

C17H25N3O15

>98% (HPLC)

H2O

C(C(=O)O)C(CC(=O)O)(C(=O)O)O.C(C1(C2C3C(N=C(NC34C(C1OC(C4O)(O2)O)O)N)O)O)O

5,9:7,10a-Dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol, 2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1), [C(S),C(S),C(S),3S,4S,5R,9R,10R,11R]-

(-20℃)

With Ice Pack

≥ 2 years