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Tetrodotoxin citrate

CAS No. 18660-81-6

Tetrodotoxin citrate( TTx citrate )

Catalog No. M12881 CAS No. 18660-81-6

Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tetrodotoxin citrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6.
  • Description
    Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6; Tetrodotoxin-sensitive sodium channel (Nav) family includes Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, and Nav1.7, the Nav1.5, Nav1.8, and Nav1.9 channels are TTX-resistant; inhibits the firing of action potentials in neurons by binding to the voltage-gated sodium channels in nerve cell membranes and blocking the passage of sodium ions into the neuron.Pain Phase 3 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TTx citrate
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    18660-81-6
  • Formula Weight
    511.3915
  • Molecular Formula
    C17H25N3O15
  • Purity
    >98% (HPLC)
  • Solubility
    H2O
  • SMILES
    C(C(=O)O)C(CC(=O)O)(C(=O)O)O.C(C1(C2C3C(N=C(NC34C(C1OC(C4O)(O2)O)O)N)O)O)O
  • Chemical Name
    5,9:7,10a-Dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol, 2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1), [C(S),C(S),C(S),3S,4S,5R,9R,10R,11R]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rogers M, et al. Assay Drug Dev Technol. 2016 Mar;14(2):109-30. 2. Frelin C, et al. J Biol Chem. 1983 Jun 25;258(12):7256-9. 3. Reiser G, et al. Brain Res. 1983 Feb 21;261(2):335-40.
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